Non-Canonical Functions of Complement in Health and Disease
Can complement be modulated to stop disease in its tracks?
Project description
We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional in the serum. Very recently, work from our lab and others have shown that complement proteins are also generated by other tissues/cells. We are studying the role of complement proteins in these new locations. This is very important since complement is being included as a therapeutic in different diseases.
Project outcome
Students will present the data obtained at meetings as posters and talks, and when the data is used in publications the students will be co-authors of the manuscripts.
Learning outcomes
Students will work on projects that will give them insights into role of complement in brain and kidney in different settings.
Project details
| Length of commitment | Longer than a semester; 6-9 months |
| Start time | Spring (February) |
| In-person, hybrid, or remote? | In-Person |
| Level of collaboration | Small group project (2-3 students) |
| Benefits | Potential Academic credit Potential stipend |
| Who is eligible | All undergraduate students |
Project mentor
Jessy Alexander
Professor
Medicine
8030D Clinical and Translational Research Center (CTRC) - 875 Ellicott St. (Downtown Buffalo)
Email: jessyale@buffalo.edu
Start the project
- Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
- After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.)
Preparation activities
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. After you’re approved to begin the project, your mentor will send the relevant materials. Please reference this when you get to Step 2 of the Preparation Phase.
- Reading articles or books
- Watching relevant videos
Keywords
medicine, health, disease, proteins, brain, kidney