Sheldon J. Park
PhD
Research Topics
Protein engineering; yeast surface display; bioinformatics; molecular dynamics simulations
Publications
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- R. Hombu, S. Neelamegham, S. Park, “Cellular and Molecular Engineering of Glycan Sialylation in Heterologous Systems”, Molecules 26, 5950 (2021).
- Q. Yang, T. A. Hughes, A. J. Kelkar, X. H. Yu, K. Cheng, S. Park, W. C. Huang, J. F. Lovell, S. Neelamegham, “Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration”, eLife 9, e61552 (2020).
- Q. Le, V. Nguyen, S. Park, “Recent advances in the engineering and application of streptavidin-like molecules”, Appl. Microbiol. Biotechnol. 103, 7355-7365 (2019).
- F. Y. Zhou, A. Kroetsch, V. P. Nguyen, X. Huang, O. Ogoke, N. Parashurama, S. Park, “High-Affinity Antibody Detection with a Bivalent Circularized Peptide Containing Antibody-Binding Domains”, Biotechnol. J. 14, 1800647 (2019).
- A. Kroetsch, C. X. Qiao, M. Heavey, L. M. Guo, D. K. Shah, S. Park, “Engineered pH-dependent recycling antibodies enhance elimination of Staphylococcal enterotoxin B superantigen in mice”, mAbs 11, 411-421 (2019).
- A. Kroetsch, B. Chin, V. Nguyen, J. Y. Gao, S. Park, “Functional expression of monomeric streptavidin and fusion proteins in Escherichia coli: applications in flow cytometry and ELISA”, Appl. Microbiol. Biotechnol. 102, 10079-10089 (2018).
- S. H. Lee, C. Y. Jin, E. Cai, P. H. Ge, Y. Ishitsuka, K. W. Teng, A. A. de thomaz, D. Nall, M. Baday, O. Jeyifous, D. Demonte, C. M. Dundas, S. Park, J. Y. Delgado, W. N. Green, P. R. Selvin, “Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes”, eLife 6, e27744 (2017).
- J. K. Mann, J. Shen, S. Park, “Enhancement of Muramyl Dipeptide-Dependent NOD2 Activity by a Self-Derived Peptide”, J. Cell. Biochem. 118, 1227-1238 (2017).
- J. K. Mann, D. Demonte, C. M. Dundas, S. Park, “Cell labeling and proximity dependent biotinylation with engineered monomeric streptavidin”, Technology 4, 152-158 (2016).
- I. Chamma, M. Letellier, C. Butler, B. Tessier, K. H. Lim, I. Gauthereau, D. Choquet, J. B. Sibarita, S. Park, M. Sainlos, O. Thoumine, “Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin”, Nat. Commun. 7, 10773 (2016).
- J. K. Mann, S. Park, “Epitope-Specific Binder Design by Yeast Surface Display”, Methods Mol. Biol. 1319, 143-154 (2015).
- D. Demonte, N. Y. Li, S. Park, “Postsynthetic Domain Assembly with NpuDnaE and SspDnaB Split Inteins”, Appl. Biochem. Biotechnol. 177, 1137-1151 (2015).
- H. Wang, S. L. Carrier, S. Park, Z. D. Schultz, “Selective TERS detection and imaging through controlled plasmonics”, Faraday Discuss. 178, 221-235 (2015).
- A. Kroetsch, S. Park, “More than one way to skin a cat: In-situ engineering of an antibody through photo-conjugated C2 domain”, Biotechnol. J. 10, 508-U197 (2015).
- D. Demonte, C. M. Dundas, S. Park, “Expression and purification of soluble monomeric streptavidin in Escherichia coli”, Appl. Microbiol. Biotechnol. 98, 6285-6295 (2014).
- C. M. Dundas, D. Demonte, S. Park, “Streptavidin-biotin technology: improvements and innovations in chemical and biological applications”, Appl. Microbiol. Biotechnol. 97, 9343-9353 (2013).
- D. Demonte, E. J. Drake, K. H. Lim, A. M. Gulick, S. Park, “Structure-based engineering of streptavidin monomer with a reduced biotin dissociation rate”, Proteins 81, 1621-1633 (2013).
- K. H. Lim, H. Huang, A. Pralle, S. Park, “Stable, high-affinity streptavidin monomer for protein labeling and monovalent biotin detection”, Biotechnol. Bioeng. 110, 57-67 (2013).
- J. K. Mann, J. F. Wood, A. F. Stephan, E. S. Tzanakakis, D. M. Ferkey, S. Park, “Epitope-Guided Engineering of Monobody Binders for in Vivo Inhibition of Erk-2 Signaling”, ACS Chemical Biology 8, 608-616 (2013).
- K. H. Lim, I. Hwang, S. Park, “Biotin-assisted folding of streptavidin on the yeast surface”, Biotechnol. Prog. 28, 276-283 (2012).
- K. H. Lim, H. Huang, A. Pralle, S. Park, “Engineered Streptavidin Monomer and Dimer with Improved Stability and Function”, Biochemistry 50, 8682-8691 (2011).
- K. H. Lim, S. R. Madabhushi, J. Mann, S. Neelamegham, S. Park, “Disulfide Trapping of Protein Complexes on the Yeast Surface”, Biotechnol. Bioeng. 106, 27-41 (2010).
- C. K. Hsu, S. Park, “Computational and mutagenesis studies of the streptavidin native dimer interface”, J. Mol. Graph. Mod. 29, 295-308 (2010).
- K. H. Lim, C. K. Hsu, S. Park, “Flow Cytometric Analysis of Genetic FRET Detectors Containing Variable Substrate Sequences”, Biotechnol. Prog. 26, 1765-1771 (2010).
- S. Szep, S. Park, E. T. Boder, G. D. Van duyne, J. G. Saven, “Structural coupling between FKBP12 and buried water”, Proteins 74, 603-611 (2009).
- I. Hwang, S. Park, “Computational design of protein therapeutics”, Drug Disc. Today: Tech. 5, 43-48 (2008).