| Awardees | BTC Institution | Title of Project |
|---|---|---|
Heather Lehman, MD | Jacobs School of Medicine and Biomedical Sciences | Defining and Treating A New Pediatric Asthma Endotype: Depression-related Asthma Mediated by the Cholinergic Pathway |
| Donald Mager, PhD, PharmD Wen Wee Ma, MB Robert Straubinger, PhD | School of Pharmacy and Pharmaceutical Sciences Roswell Park Comprehensive Cancer Center | Pharmacological Network Analysis and Modeling of Complex Chemotherapeutic Regimens in Pancreatic Cancer: Pharmacodynamic Design of Novel Combination Therapies |
| Jun Qu, PhD John Canty, MD Jianmin Wang, PhD | School of Pharmacy and Pharmaceutical Sciences Jacobs School of Medicine and Biomedical Sciences Roswell Park Comprehensive Cancer Center | Novel Circulating Biomarkers for Sudden Cardiac Death |
| Jerry Richards, PhD Leonard Epstein, PhD Katelyn Carr, PhD Larry Hawk, PhD | Research Institute on Addictions Jacobs School of Medicine and Biomedical Sciences College of Arts and Sciences | Effects of Nicotine on the Reinforcing Value of Alternatives to Eating in Animals |
| Ferdinand Schweser, PhD David Poulsen, PhD John Leddy, MD Asla Pitkänen, MD, PhD | Jacobs School of Medicine and Biomedical Sciences | Investigation of Brain Calcification in Mild Traumatic Brain Injury Using Advanced Quantitative Magnetic Susceptibility MRI |
| Jack Sullivan, MD, PhD Jonathan Lovell, PhD | Jacobs School of Medicine and Biomedical Sciences School of Engineering and Applied Sciences | Novel Theranostic Approaches to Treat Wet Age-related Macular Degeneration, Proliferative Diabetic Retinopathy, and Other Retinal Vascular Diseases |
| Kinga Szigeti, MD, PhD Gabriela Popescu, PhD Brian Trummer, MD, PhD | Jacobs School of Medicine and Biomedical Sciences | Narrowing the Gap in the Genetic Architecture of Alzheimer's Disease |
| Two joint proposals on precision medicine with University of Rochester CTSA hub were funded 2016-17: |
| Awardees | BTC Institution | Title of Project |
|---|---|---|
Joseph Barbi, PhD | Roswell Park Comprehensive Cancer Center | The Role of CCR2 Blockade in Patients with Locally Advanced Pancreas Cancer |
Sanjay Sethi, MD | Jacobs School of Medicine and Biomedical Sciences | Epigenetics profiling of Exacerbation Susceptibility in COPD |
1. Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D’Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J Exp Med. 2018 Mar 5;215(3):941-961. PMCID: PMC5839751
2. Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ. Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism. J Proteomics. 2017 May 8;160:84-105. PMC5455150
3. Bima A, Pezic A, Sun C, Cameron FJ, Rodda C, Mei IV, Chiaroni-Clarke R, Dwyer T, Kemp A, Qu J, Carlin J, Ellis JA, Ponsonby AL. Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children. J Pediatr Endocrinol Metab. 2017 May 1;30(5):531-541. PMID: 28315849
4. Cáceres TB, Thakur A, Price OM, Ippolito N, Li J, Qu J, Acevedo O, Hevel JM. Phe71 in Type III Trypanosomal Protein Arginine Methyltransferase 7 (TbPRMT7) Restricts the Enzyme to Monomethylation. Biochemistry. 2018 Feb 27;57(8):1349-1359. PMID: 29378138
5. Fu W, An B, Wang X, Qu J. Key considerations for LC/MS analysis of biotherapeutics in tissues. Bioanalysis. 2017 Sep;9(18):1349-1352. PMID: 28920446
6. Gururaj S, Evely KM, Pryce KD, Li J, Qu J, Bhattacharjee A. Protein Kinase A induced internalization of Slack channels from the neuronal membrane occurs by Adaptor Protein-2/Clathrin mediated endocytosis. J Biol Chem. 2017 Nov 24;292(47):19304-19314. PMCID: PMC5702670
7. Ihnatovych I, Lew A, Lazar E, Sheng A, Kellermayer T, Szigeti K. Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells. Stem Cells Int. 2018 Jun 27;2018:3983090. PMCID: PMC6040240
8. Li Y, Guo J, Li J, Yang N, Shen H, Frangou C, Wilson K, Zhang Y, Sudol M, Farooq A, Qu J, Zhang J. Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation. Cell Cycle. 2016 Sep 16;15(18):2497-505. PMCID: PMC5026814
9. Liu G, Cheng K, Lo CY, Li J, Qu J, Neelamegham S. A comprehensive, open-source platform for mass spectrometry based glycoproteomics data analysis. Mol Cell Proteomics. 2017 Nov;16(11):2032-2047. PMCID: PMC5672007
10. Luo D, Goel S, Liu HJ, Carter KA, Jiang D, Geng J, Kutyreff CJ, Engle JW, Huang WC, Shao S, Fang C, Cai W, Lovell JF. Intrabilayer 64Cu Labeling of Photoactivatable, Doxorubicin-Loaded Stealth Liposomes. ACS Nano. 2017 Dec 26;11(12):12482-12491. PMCID: PMC6004286
11. Ma JH, Shen S, Wang JJ, He Z, Poon A, Li J, Qu J, Zhang SX. Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model. Sci Rep. 2017 May 18;7(1):2062. PMCID: PMC5437025
12. Martin CD, Bool HM, George AM, Carr KA, Epstein LH, Hawk LW Jr, Richards JB. Social reinforcement as alternative to sucrose reinforcement is increased by nicotine and methylphenidate in male Fischer-344 rats. Psychopharmacology (Berl). 2018 Apr 24. PMID: 29691605
13. Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J. Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry. Mass Spectrom Rev. 2017 Nov;36(6):734-754. PMID: 27097288
14. Shen X, Shen S, Li J, Hu Q, Nie L, Tu C, Wang X, Orsburn B, Wang J, Qu J. An IonStar experimental strategy for MS1 ion current-based quantification using ultra-high-field Orbitrap: reproducible, in-depth and accurate protein measurement in large cohorts. J Proteome Res. 2017 Jul 7;16(7):2445-2456. PMCID: PMC5914162
15. Shen X, Shen S, Li J, Hu Q, Nie L, Wang X, Poulsen D, Orsburn B, Wang J, Qu J. IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts. Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4767-E4776. PMID: 29743190
16. Tian Y, Jacinto MP, Zeng Y, Yu Z, Qu J, Liu WR, Lin Q. Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking. J Am Chem Soc. 2017 May 3;139(17):6078-6081. PMCID: PMC5423124
17. Tu C, Bu Y, Vujcic M, Shen S, Li J, Qu M, Hangauer D, Clements J, Qu J. Ion Current-based Proteomic Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation. J Proteome Res. 2016 Sep 2;15(9):3147-57. PMID: 27480135
18. Tu C, Li J, Shen S, Sheng Q, Shyr Y, Qu J. Performance Investigation of Proteomic Identification by HCD/CID Fragmentations in Combination with High/Low-Resolution Detectors on a Tribrid, High-Field Orbitrap Instrument. PLoS One. 2016 Jul 29;11(7):e0160160. PMCID: PMC4966894
19. Tu C, Mojica W, Straubinger RM, Li J, Shen S, Qu M, Nie L, Roberts R, An B, Qu J. Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients. Proteomics Clin Appl. 2017 May;11(5-6). PMCID: PMC5418098
20. Tu C, Shen S, Sheng Q, Shy Y, Qu J. Peptide-Retrieval Strategy Enables Significant Improvement of Quantitative Performance Without Compromising Confidence of Identification. J Proteomics. 2017 Jan 20;152:276-282. PMID: 27903464
21. Wang X, Niu J, Li J, Shen X, Shen S, Straubinger RM, Qu J. Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-Scale, Ion-Current-Based Quantitative Proteomics (IonStar). Mol Cell Proteomics. 2018 Apr;17(4):655-671. PMCID: PMC5880105
22. Weil B, Young R, Shen X, Qu J, Malhotra S, Canty J. Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine. JACC Basic Transl Sci. 2017 Apr;2(2):105-114. PMCID: PMC5624553
23. Welle KA, Zhang T, Hyrohorenko JR, Shen S, Qu J, Ghaemmaghami S. Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing. Mol Cell Proteomcis. 2016 Dec;15(12):3551-3563. PMCID: PMC5141271
24. Zhang M, An B, Qu Y, Shen S, Fu W, Chen YJ, Wang X, Young R, Canty JM Jr, Balthasar JP, Murphy K, Bhattacharyya D, Josephs J, Ferrari L, Zhou S, Bansal S, Vazaei F, Qu J. Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics. Anal Chem. 2018 Feb 6;90(3):1870-1880. PMCID: PMC5960441
25. Zhou S, Vazvaei F, Ferrari L, Qu J. Practical considerations on in enhancing LC-–MS sensitivity for therapeutic protein bioanalysis. Bioanalysis. 2017 Sep;9(18):1353-1356. PMID: 28956634
26. Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ. Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells. Front Pharmacol. 2018 Feb 19;9:84. PMCID: PMC5827530