An antiretroviral drug for HIV, methadone for heroin addiction, a birth control pill and an antidepressant. For some AIDS patients, this is a daily medication regimen. How do all of these substances affect how HIV drugs work and how do HIV drugs, in turn, affect the other drugs a patient takes? That question is at the heart of research being conducted by the University at Buffalo's Laboratory for Antiviral Research, where researchers are developing innovative new methods of testing the blood and cells of HIV patients for these interactions.