Neuroscientists receive grant to study shuttling proteins

Two researchers in UB’s Research Institute on Addictions will expand on their work exploring the brain’s endocannabinoid system thanks to a two-year, $427,000 grant from the National Institute on Drug Abuse.

Panayotis (Peter) Thanos and Samir Haj-Dahmane, senior research scientists at RIA, seek to identify potential targets for new drug therapies to fight addiction through their research on the role of fatty acid binding proteins (FABPs) in the brain’s endocannabinoid system.

Endocannabinoids are naturally produced lipids in the brain that control numerous physiological and behavior functions, including stress, addiction, memory, appetite and pain regulation. In a recently published study in the Proceedings of the National Academy of Sciences, Haj-Dahmane, Thanos and their co-authors showed that a certain fatty acid binding protein — FABP5 — is key to how endocannabinoids are transported to engage their receptor targets in the brain.

“We know that dysregulation in endocannabinoid signaling contributes to the development and persistence of addictive behaviors,” Thanos says. “Therefore, understanding the various mechanisms of this system is required for a better understanding of the neurobiology of addiction-related disorders and the development of effective treatments.”

The multidisciplinary translational study will focus on the role of FABP5 in endocannabinoid signaling in the effects of cocaine abuse on the brain. Thanos and Haj-Dahmane will collaborate with researchers from Stony Brook University in a continuation of work initially supported by SUNY REACH (Research Excellence in Academic Health), a program to unify and advance the research vision of New York State’s public academic health centers and their integrated medical schools.