Study finds link between poor diet, age-related macular degeneration

Participants who ate a diet high in red and processed meat, fried food, refined grains and high-fat dairy were three times more likely to develop an eye condition that damages the retina and affects a person’s central vision, according to the results of a UB study.

The condition is called late-stage age-related macular degeneration (AMD). AMD is an irreversible condition that affects a person’s central vision, taking away their ability to drive, among other common daily activities.

“Treatment for late, neovascular AMD is invasive and expensive, and there is no treatment for geographic atrophy, the other form of late AMD that also causes vision loss. It is in our best interest to catch this condition early and prevent development of late AMD,” says Shruti Dighe, who conducted the research as part of her master’s degree in epidemiology at the School of Public Health and Health Professions.

And that’s why the finding that diet plays a role in AMD is so intriguing, adds Dighe, who is now pursuing her PhD in cancer sciences at Roswell Park Comprehensive Cancer Center.

It turns out that a Western dietary pattern, one defined as high in consumption of red and processed meat, fried food, refined grains and high-fat dairy, may be a risk factor for developing late AMD. However, a Western diet was not associated with development of early AMD in the study published in the British Journal of Ophthalmology.

The authors studied the occurrence of early and late AMD over approximately 18 years of follow-up among participants in the Atherosclerosis Risk in Communities (ARIC) Study. Dighe and colleagues used data on 66 different foods that participants self-reported consuming between 1987 and 1995 and identified two dietary patterns in this cohort — Western and what researchers commonly refer to as “prudent” (healthy) — that best explained the greatest variation between diets.

“What we observed in this study was that people who had no AMD or early AMD at the start of our study and reported frequently consuming unhealthy foods were more likely to develop vison-threatening, late-stage disease approximately 18 years later,” says Amy Millen, the study’s senior author and associate professor and associate chair of the Department of Epidemiology and Environmental Health.

This U.S.-based study is one of the first examining dietary patterns and development of AMD over time. The other studies were conducted in European cohorts.

Early AMD is asymptomatic, meaning that people often don’t know they have it. To catch it, a physician would have to review a photo of the person’s retina, looking for pigmentary changes and development of drusen, or yellow deposits made up of lipids. With late AMD, there could be either atrophy or a buildup of new blood vessels in the part of the eye known as the macula.

“When people start developing these changes, they will begin to notice visual symptoms. Their vision will start diminishing,” Dighe says. “This is advanced or late-stage AMD.”

But not everyone who has early AMD progresses to the more debilitating late stage.

To date, most research has been conducted on specific nutrients — such as high-dose antioxidants — that seem to have a protective effect. But, Dighe explains, people consume a variety of foods and nutrients, not just one or two, and that’s why looking at dietary patterns helps tell more of the story.

“Our work provides additional evidence that diet matters,” Millen adds. “From a public health standpoint, we can tell people that if you have early AMD, it is likely in your best interest to limit your intake of processed meat, fried food, refined grains and high-fat dairy to preserve your vision over time.”