News
Air pollution exposure linked
to premenopausal breast cancer
-
Print -
Comments
-
“To our knowledge, this is the first study to examine exposure to ambient air pollution at key points in a woman’s lifetime.”
Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, UB researchers have shown.
The findings indicate that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment and assuring healthy tissues.
Methylation is a chemical process that has been implicated in determining which genes in a cell are active, a process essential to normal cellular function.
Women with breast cancer who lived in a region with more air pollution were more likely to have the alteration in the DNA in their tumor than those who lived in a less-polluted region, results show.
Higher air pollution concentration at the time of first childbirth also was associated with changes in p16, a gene involved in tumor suppression, according to findings.
Results of the research were presented earlier this month at the 2011 American Association for Cancer Research annual meeting in Orlando.
“To our knowledge, this is the first study to examine exposure to ambient air pollution at key points in a woman’s lifetime,” says lead investigator Katharine Dobson, an epidemiology doctoral student and research assistant in the Department of Social and Preventive Medicine.
“The investigation looked for an association between exposure to pollution and alterations to DNA that influence the presence or absence of key proteins. Such genetic changes are thought to be major contributors to cancer development and progression, including at very early stages,” Dobson says.
The study is based on data from the Western New York Exposures and Breast Cancer (WEB) study, which collected information from 1,170 women with recently diagnosed breast cancer and 2,116 healthy women who lived in Erie and Niagara counties between 1996 and 2001. This research involved only cancer cases.
Participants provided information on where they were born, where they lived at the time of their first menstrual period and, if they had children, where they lived when they bore their first child. Data from air monitors operating in the relevant time periods was used to determine the amount of particulate matter at each participant’s residence at those time periods. Air pollution data from 87 sites in Western New York was matched with residence location at year of birth, year of menarche and year of first childbirth.
“We found that decreased E-cadherin promoter methylation was associated with higher exposure at birth, and increased p16 methylation with higher exposure at the time of a first childbirth,” says Dobson.
“For breast cancer cases, menopausal status appeared to modify the association between air pollution exposure and E-cadherin promoter methylation, with premenopausal women more susceptible to these early exposures than postmenopausal women.”
More research is needed to determine the role of air pollution in DNA methylation in breast cancer development and progression, and to address changing air pollution contents and levels over time, Dobson notes.
Other contributors to the study are Jo L. Freudenheim, Menghua Tao, Jing Nie and Matthew Bonner, all from UB, and researchers from Lombardi Comprehensive Cancer Center, Georgetown University; Roswell Park Cancer Center; Potomac Hospital, Woodbridge, Va.; and University of Nevada Health Sciences System, Las Vegas.
The study was funded by the National Cancer Institute.
Reader Comments