University at Buffalo - The State University of New York

Published: November 8, 2007

By ELLEN GOLDBAUM
Contributing Editor

What makes some clays such powerful antimicrobial agents capable of killing MRSA and other virulent bacteria? It's a question that UB researchers have been studying for several years.

Rossman Glese and colleagues are studying the surface characteristics of naturally occurring antimicrobial clays, some of which have been shown to kill MRSA.
PHOTO: ELLEN GOLDBAUM

With funding from the National Institutes of Health-National Center for Complementary and Alternative Medicine, UB geologists are studying the surface characteristics of naturally occurring antimicrobial clays, including some clays from France, to determine why they are such effective killers of bacteria.

Researchers from Arizona State University's School of Earth and Space Exploration, to whom the UB researchers are under subcontract on that grant, have recently shown that French clays can destroy Methicillin-Resistant Staphylococcus Aureus, also called MRSA.

The UB researchers also have modified and patented Bioclay, a different type of clay that is highly successful in destroying a range of bacterial agents. It will soon be tested against MRSA.

Some of the UB researchers' results on the surface characteristics of the French clays were presented last month at the annual meeting of the Geological Society of America.

Rossman Giese, professor of geology in the College of Arts and Sciences, and Tracy Bank, assistant professor of geology, are using several techniques to study the French clays, including atomic force microscopy.

In particular, they study the weak interactions that are responsible for the stickiness of clay particles.

"We look at the attraction or repulsion between natural and modified clays and bacteria," said Giese.

The UB researchers found very little interaction between the French clays and one kind of bacterium.

For Bioclay, on the other hand, the killing mechanism may be quite different. Unlike antibiotics, which are essentially a chemical weapon against bacteria, Giese says he and his colleagues have reason to believe that Bioclay kills through purely physical means.

"The bacterium has to come into physical contact with Bioclay in order for something to happen," Giese said.

That contact turns deadly.

"The antimicrobial agents in the Bioclay disrupt the cell wall of the bacterium, causing the bacterium to leak to death," he explained. "The nice thing about that is that it is unlikely that the bacterium can evolve to avoid it, so resistance to this antimicrobial clay is unlikely to become a problem."

Bioclay has been very effective in lab testing, Giese said.

"Our studies show that when we mix a bit of our modified clay at very low levels into sewage sludge that contains all kinds of bacteria, the modified clay kills everything," said Giese. "Nothing in the sewage sludge will grow in it."

The formulation developed by Giese and colleagues in the geology department and in the School of Medicine and Biomedical Sciences was recently licensed to a Buffalo start-up company, also called Bioclay Inc.

The first application for that product is to treat HEPA filters in hospitals with the clay in order to trap and kill potentially lethal bacteria.

In addition to Giese, other UB researchers who developed Bioclay are Pat Costanzo, former faculty member in the Department of Geology; Paul J. Kostyniak, professor of pharmacology and toxicology and director of the Toxicology Research Center; and Joseph A. Syracuse, research scientist with the center.