News and Updates
Check out the latest news, publications and highlights from researchers in the UB Microbiome Center.
Recent News
Recent Publications
Patricia Diaz
- Randomized Trial to Test a Chemo-Mechanical Antiplaque Regimen as Adjunct to Periodontal Therapy. Li L., Hayashi-Okada Y., Falkner K.L., Cervi S., Andrusz S., Shimizu Y., Zambon J.J., Kirkwood K.L., Schifferle R.E., Diaz P.I. JDR Clin Trans Res. 2024 Apr;9(2):160-169. doi: 10.1177/23800844231167065. Epub 2023 May 6. PMID: 37148266 Clinical Trial.
- Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals. Koo S.S., Fernandes J.G., Li L., Huang H., Aukhil I., Harrison P., Diaz P.I., Shaddox L.M. J Periodontol. 2024 Jul;95(7):650-661. doi: 10.1002/JPER.23-0504. Epub 2024 Mar 13. PMID: 38476115
- Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis.
Kim T.S., Silva L.M., Theofilou V.I., Greenwell-Wild T., Li L., Williams D.W., Ikeuchi T., Brenchley L.; NIDCD/NIDCR Genomics and Computational Biology Core; Bugge T.H., Diaz P.I., Kaplan M.J., Carmona-Rivera C., Moutsopoulos N.M. J Exp Med. 2023 Sep 4;220(9):e20221751. doi: 10.1084/jem.20221751. Epub 2023 Jun 1. PMID: 37261457 Free PMC article. - Epithelial-derived interleukin-23 promotes oral mucosal immunopathology. Kim T.S., Ikeuchi T., Theofilou V.I., Williams D.W., Greenwell-Wild T., June A., Adade E.E., Li L., Abusleme L., Dutzan N., Yuan Y., Brenchley L., Bouladoux N., Sakamachi Y.; NIDCD/NIDCR Genomics and Computational Biology Core; Palmer R.J. Jr., Iglesias-Bartolome R., Trinchieri G., Garantziotis S., Belkaid Y., Valm A.M., Diaz P.I., Holland S.M., Moutsopoulos N.M. Immunity. 2024 Apr 9;57(4):859-875.e11. doi: 10.1016/j.immuni.2024.02.020. Epub 2024 Mar 20. PMID: 38513665
- Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis. Shehabeldin M., Gao J., Cho Y., Chong R., Tabib T., Li L., Smardz M., Gaffen S.L., Diaz P.I., Lafyatis R., Little S.R., Sfeir C. Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2400528121. doi: 10.1073/pnas.2400528121. Epub 2024 Aug 26. PMID: 39186644
Chelsie Armbruster
- Johnson AO, Shipman BM, Hunt BC, Learman BS, Brauer AL, Zhou SP, Hageman Blair R, De Nisco NJ, Armbruster CE. Function and contribution of two putativeEnterococcus faecalis glycosaminoglycan degrading enzymes to bacteremia and catheter-associated urinary tract infection. Infection and Immunity. 2024 Jul 11;92(7):e0019924.
- Hunt, B. C., Brix, V., Vath, J., Guterman, B. L., Taddei, S. M., Learman, B. S., Brauer, A. L., Shen, S., Qu, J., & Armbruster, C. E. (2024). Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease. bioRxiv : the preprint server for biology, 2023.03.17.533237. https://doi.org/10.1101/2023.03.17.533237
Marcella Baiz
- Baiz, M. D., Benavides C, A., Miller, E. T., Wood, A. W., & Toews, D. P. (2023). Gut microbiome composition better reflects host phylogeny than diet diversity in breeding wood‐warblers. Molecular ecology, 32(2), 518-536.
- Baiz, M. D., Wood, A. W., & Toews, D. P. (2024). Association between the gut microbiome and carotenoid plumage phenotype in an avian hybrid zone. Proceedings of the Royal Society B, 291(2021), 20240238.
Yolanda Huang
- Huang, Y.Y.; Price, M.N.; Hung, A.; Gal-Oz, O.; Tripathi, S.; Smith, C.W.; Ho, D.; Carion, H.; Deutschbauer, A.M.; Arkin, A.P. (2024) Barcoded overexpression screens in gut Bacteroidales identify genes with roles in carbon utilization and stress resistance. Nature Communications (Aug)(15): 6618.
Ryan Hunter
- To Compare the Effects of a Standard Versus Hydrophilic Polymer Coated Airway Stent in a Porcine Model: A Randomized, Single-Blinded Study. RJ Cho, K Kadowaki, D Seelig, DE Glumac, LA Kent, RC Hunter. Journal of Bronchology & Interventional Pulmonology 31 (2), 132-138.
- Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut. P. Vangay, T Ward, S Lucas, LK Beura, D Sabas, M Abramson, L Till, Gut microbes 15 (2), 2266627.
- Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities. JNV Martinson, JM Chacón, BA Smith, AR Villarreal, RC Hunter, The ISME Journal 17 (12), 2270-2278.
- High-throughput quantification of microbial-derived organic acids in mucin-rich samples via reverse phase high performance liquid chromatography. AR Villarreal, SK Lucas, JR Fletcher, RC Hunter. Journal of medical microbiology 72 (6), 001708.
- Plasma‐induced inactivation of Staphylococcus aureus biofilms: The role of atomic oxygen and comparison with disinfectants and antibiotics. SR Nandula, VSSK Kondeti, C Phan, J Wang, MR Penningroth, Plasma Processes and Polymers 20 (1), 2200147.
- Staphylococcus aureus overcomes anaerobe-derived short-chain fatty acid stress via FadX and the CodY regulon. JR Fletcher, AR Villareal, MR Penningroth, RC Hunter. Journal of bacteriology 204 (5), e00064-22.
- Respiratory influenza virus infection causes dynamic tuft cell and innate lymphoid cell changes in the small intestine. SN Roach, JK Fiege, FK Shepherd, TD Wiggen, RC Hunter, RA Langlois. Journal of virology 96 (9), e00352-22.
- Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. K Agaronyan, L Sharma, B Vaidyanathan, K Glenn, S Yu, C Annicelli, Immunity 55 (5), 895-911. e10.
Kathryn Kauffman
- 2023 | Jonathon Baker, Jessica Mark Welch, Kathryn M. Kauffman, Jeffrey McLean, Xuesong He. The oral microbiome: diversity, biogeography, and human health. Nature Reviews Microbiology Sep 12, 2023
- 2023 | Cole B. Matrishin, Elaine M. Haase, Floyd E. Dewhirst, Jessica L. Mark Welch, Fabiola Miranda-Sanchez, Donald C. MacFarland, Kathryn M. Kauffman. Phages are unrecognized players in the ecology of the oral pathogen Porphyromonas gingivalis. Microbiome July 25, 2023.
Keith Kirkwood
- Sohn J, Li L, Zhang L, Genco RJ, Falkner KL, Tettelin H, Rowsam AM, Smiraglia DJ, Novak JM, Diaz PI, Sun Y, Kirkwood KL. Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn's disease. Cell Rep. 2023 Feb 28;42(2):112120. doi: 10.1016/j.celrep.2023.112120. Epub 2023 Feb 13. PMID: 36774550; PMCID: PMC10415533.
- Santos TPMD, Hicks WL Jr, Magner WJ, Al Afif A, Kirkwood KL. Metabolic and Aging Influence on Anticancer Immunity in Oral Cancer. J Dent Res. 2024 Sep; 103(10):953-961. doi: 10.1177/00220345241264728. Epub 2024 Aug 26. PMID: 39185914.
Stefan Ruhl
- Ghosh S., Ahearn C.P., Isabella C.R., Marando V.M., Dodge G.J., Bartlett H., McPherson R.L., Dugan A.E., Jain S., Neznanova L., Tettelin H., Putnik R., Grimes C.L., Ruhl S., Kiessling L.L., Imperiali B. (2023)
Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host–microbe interactions with oral commensals. Proc. Natl. Acad. Sci. 120 (22) e2216304120; PMID: 37216558; PMCID: PMC10235990 (available on 2023-11-22) DOI: 10.1073/pnas.2216304120
Ashu Sharma
- Settem RP, Ruscitto A, Chinthamani S, Honma K, Sharma A. Tannerella forsythia scavenges Fusobacterium nucleatum secreted NOD2 stimulatory molecules to dampen oral epithelial cell inflammatory response. Mol Oral Microbiol. 2024 Apr;39(2):40-46. doi: 10.1111/omi.12429. Epub 2023 Jul 17. PubMed PMID: 37459655; PubMed Central PMCID: PMC10792118.
- Hyland SN, Chinthamani S, Ratna S, Wodzanowski KA, Sandles LD, Honma K, Leimkuhler-Grimes C, Sharma A. Bioorthogonal Labeling and Click-Chemistry-Based Visualization of the Tannerella forsythia Cell Wall. Methods Mol Biol. 2024;2727:1-16. doi: 10.1007/978-1-0716-3491-2_1. PubMed PMID: 37815704.
- Honma K, Sasaki H, Hamada N, Sharma A. An Extracytoplasmic Function Sigma/Anti-Sigma Factor System Regulates β-Glucanase Expression in Tannerella forsythia in Response to Fusobacterium nucleatum Sensing. J Bacteriol. 2022 Dec 20;204(12):e0031322. doi: 10.1128/jb.00313-22. Epub 2022 Nov 30. PubMed PMID: 36448787; PubMed Central PMCID: PMC9765289.
Michelle Visser
- Anselmi NK, Vanyo ST, Clark ND, Rodriguez DML, Jones MM, Rosenthal S, Patel D, Marconi RT, Visser MB. Topology and functional characterization of major outer membrane proteins of Treponema maltophilum and Treponema lecithinolyticum. Mol Oral Microbiol. 2024 Sep 12. doi: 10.1111/omi.12484. Epub ahead of print. PMID: 39263909.
Jean Wactawski-Wende
- Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia. Gaber M, Wilson AS, Millen AE, Hovey KM, LaMonte MJ, Wactawski-Wende J, Ochs-Balcom HM, Cook KL. Microbiome. 2024 Oct 4;12(1):192. doi: 10.1186/s40168-024-01901-1. PMID: 39367431 Free PMC article.
- Association Between Healthy Eating Index-2020 and Oral Microbiome Among Postmenopausal Women. Yue Y, Hovey KM, Wactawski-Wende J, LaMonte MJ, Andrews CA, Diaz PI, McSkimming DI, Buck M, Sun Y, Millen AE. J Nutr. 2024 Aug 31:S0022-3166(24)00474-7. doi: 10.1016/j.tjnut.2024.08.023. Online ahead of print. PMID: 39218399
- Association between dietary patterns and periodontal disease: The OsteoPerio cohort study. Yue Y, Hovey KM, LaMonte MJ, Wactawski-Wende J, Andrews CA, Millen AE. J Clin Periodontol. 2024 Jul;51(7):863-873. doi: 10.1111/jcpe.13979. Epub 2024 Mar 27. PMID: 38538208