Natesh Parashurama
MD PhD
Research Topics
Liver stem cell biology; differentiation; cell therapy; organogenesis; disease modeling; tissue engineering; multimodality molecular imaging; monitoring molecular events in living subjects
Publications
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- I. Warren, M. M. Moeller, D. Guiggey, A. L. X. D. Chiang, M. Maloy, O. Ogoke, T. Groth, T. Mon, S. Meamardoost, X. J. Liu, S. Thompson, A. Szeglowski, R. Thompson, P. T. Chen, R. Paulmurugan, M. L. Yarmush, S. Kidambi, N. Parashurama, “FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells”, Faseb J. 37, e22652 (2023).
- N. Parashurama, “A personal tribute to Sanjiv Sam Gambhir MD PHD”, Nanotheranostics 6, 123-124 (2022).
- O. Ogoke, D. Guiggey, T. Mon, C. Shamul, S. Ross, S. Rao, N. Parashurama, “Spatiotemporal imaging and analysis of mouse and human liver bud morphogenesis”, Dev. Dyn. 251, 662-686 (2022).
- O. Ogoke, O. Yousef, C. Ott, A. Kalinousky, W. Lin, C. Shamul, S. Ross, N. Parashurama, “Modeling Liver Organogenesis by Recreating Three-Dimensional Collective Cell Migration: A Role for TGF beta Pathway”, Front. Bioeng. Biotechnol. 9, 621286 (2021).
- O. Ogoke, M. Maloy, N. Parashurama, “The science and engineering of stem cell-derived organoids-examples from hepatic, biliary, and pancreatic tissues”, Biol. Rev. 96, 179-204 (2021).
- M. H. Maloy, M. A. Ferrer, N. Parashurama, “In Vivo Differentiation of Stem Cell-derived Human Pancreatic Progenitors to Treat Type 1 Diabetes”, Stem Cell Rev. Rep. 16, 1139-1155 (2020).
- M. Zabala, N. A. Lobo, J. Antony, L. S. Heitink, G. S. Gulati, J. Lam, N. Parashurama, K. Sanchez, M. Adorno, S. S. Sikandar, A. H. Kuo, D. L. Qian, T. Kalisky, S. Sim, L. N. Li, F. M. Dirbas, G. Somlo, A. Newman, S. R. Quake, M. F. Clarke, “LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis”, Cell Stem Cell 27, 284-+ (2020).
- F. Y. Zhou, A. Kroetsch, V. P. Nguyen, X. Huang, O. Ogoke, N. Parashurama, S. Park, “High-Affinity Antibody Detection with a Bivalent Circularized Peptide Containing Antibody-Binding Domains”, Biotechnol. J. 14, 1800647 (2019).
- M. Willadsen, M. Chaise, I. Yarovoy, A. Q. Zhang, N. Parashurama, “Engineering molecular imaging strategies for regenerative medicine”, Bioeng. Transl. Med. 3, 232-255 (2018).
- K. E. Denson, A. L. Mussell, H. Shen, A. Truskinovsky, N. Yang, N. Parashurama, Y. M. Chen, C. Frangou, F. J. Yang, J. M. Zhang, “The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis”, Sci. Rep. 8, 6449 (2018).
- A. Momeni, S. Neelamegham, N. Parashurama, “Current challenges for the targeted delivery and molecular imaging of stem cells in animal models”, Bioengineered 8, 316-324 (2017). PDF
- O. Ogoke, J. Oluwole, N. Parashurama, “Bioengineering considerations in liver regenerative medicine”, J. Biol. Eng. 11, 46 (2017).
- N. Parashurama, B. C. Ahn, K. Ziv, K. Ito, R. Paulmurugan, J. K. Willmann, J. Chung, F. Ikeno, J. C. Swanson, D. R. Merk, J. K. Lyons, D. Yerushalmi, T. Teramoto, H. Kosuge, C. N. Dao, P. Ray, M. Patel, Y. F. Chang, M. Mahmoudi, J. E. Cohen, A. B. Goldstone, F. Habte, S. Bhaumik, S. Yaghoubi, R. C. Robbins, R. Dash, P. C. Yang, T. J. Brinton, P. G. Yock, M. V. Mcconnell, S. S. Gambhir, “Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging”, Radiology 280, 826-836 (2016).
- N. Parashurama, B. C. Ahn, K. Ziv, K. Ito, R. Paulmurugan, J. K. Willmann, J. Chung, F. Ikeno, J. C. Swanson, D. R. Merk, J. K. Lyons, D. Yerushalmi, T. Teramoto, H. Kosuge, C. N. Dao, P. Ray, M. Patel, Y. F. Chang, M. Mahmoudi, J. E. Cohen, A. B. Goldstone, F. Habte, S. Bhaumik, S. Yaghoubi, R. C. Robbins, R. Dash, P. C. Yang, T. J. Brinton, P. G. Yock, M. V. Mcconnell, S. S. Gambhir, “Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction”, Radiology 280, 815-825 (2016).
- B. C. Ahn*, N. Parashurama*, M. Patel, K. Ziv, S. Bhaumik, S. S. Yaghoubi, R. Paulmurugan, S. S. Gambhir, “Noninvasive Reporter Gene Imaging of Human Oct4 (Pluripotency) Dynamics During the Differentiation of Embryonic Stem Cells in Living Subjects”, Mol. Imaging. Biol. 16, 865-876 (2014).
- T. D. O'Sullivan*, R. T. Heitz*, N. Parashurama*, D. B. Barkin, B. A. Wooley, S. S. Gambhir, J. S. Harris, O. Levi, “Real-time, continuous, fluorescence sensing in a freely-moving subject with an implanted hybrid VCSEL/CMOS biosensor”, Biomed. Opt. Express 4, 1332-1341 (2013).
- M. Kotsuma*, N. Parashurama*, B. R. Smith, J. Wo, K. Ito, S. S. Gambhir, “Applications for intravital microscopy imaging in the mammary fat pad and lymph node”, IntraVital 1, 69-76 (2012).
- N. Parashurama, N. A. Lobo, K. Ito, A. R. Mosley, F. G. Habte, M. Zabala, B. R. Smith, J. Lam, I. L. Weissman, M. F. Clarke, S. S. Gambhir, “Remodeling of Endogenous Mammary Epithelium by Breast Cancer Stem Cells”, Stem Cells 30, 2114-2127 (2012).
- N. Parashurama, T. D. O'Sullivan, A. de la zerda, P. El kalassi, S. Cho, H. G. Liu, R. Teed, H. Levy, J. Rosenberg, Z. Cheng, O. Levi, J. S. Harris, S. S. Gambhir, “Continuous sensing of tumor-targeted molecular probes with a vertical cavity surface emitting laser-based biosensor”, J. Biomed. Opt. 17, 117004 (2012).
- K. Ito, B. R. Smith, N. Parashurama, J. K. Yoon, S. Y. Song, C. Miething, P. Mallick, S. Lowe, S. S. Gambhir, “Unexpected Dissemination Patterns in Lymphoma Progression Revealed by Serial Imaging within a Murine Lymph Node”, Cancer Res. 72, 6111-6118 (2012).
- I. Banerjee, S. Maiti, N. Parashurama, M. Yarmush, “An integer programming formulation to identify the sparse network architecture governing differentiation of embryonic stem cells”, Bioinformatics 26, 1332-1339 (2010).
- T. O'Sullivan, E. A. Munro, N. Parashurama, C. Conca, S. S. Gambhir, J. S. Harris, O. Levi, “Implantable semiconductor biosensor for continuous in vivo sensing of far-red fluorescent molecules”, Opt. Express 18, 12513-12525 (2010).
- N. Parashurama, Y. Nahmias, C. H. Cho, D. van poll, A. W. Tilles, F. Berthiaume, M. L. Yarmush, “Activin afters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels”, Stem Cells 26, 474-484 (2008).
- C. H. Cho, N. Parashurama, E. Y. H. Park, K. Suganuma, Y. Nahniias, J. Park, A. W. Tilles, F. Berthiaume, M. L. Yarmush, “Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure”, Faseb J. 22, 898-909 (2008).
- J. Park, C. H. Cho, N. Parashurama, Y. W. Li, F. Berthiaume, M. Toner, A. W. Tilles, M. L. Yarmush, “Microfabrication-based modulation of embryonic stem cell differentiation”, Lab Chip 7, 1018-1028 (2007).
- W. L. Hicks, L. A. Hall, R. Hard, J. Gardella, F. Bright, N. Parashurama, J. Lwebuga-mukasa, L. Sigurdson, “Keratinocyte growth factor and autocrine repair in airway epithelium”, Arch. Otolaryngol. Head Neck Surg. 130, 446-449 (2004).
- R. M. Ezzell, W. H. Goldmann, N. Wang, N. Parashurama, D. E. Ingber, “Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton”, Exp. Cell Res. 231, 14-26 (1997).